Publications

Xu H, Wu L, Nguyen H, Mesa KR, Raghavan V, Episkopou V, Littman DR. Arkadia-SKI/SnoN signaling cascade differentially regulates TGF-β-induced iTreg and Th17 cell differentiation. JEM. 2021. 218 (11): e20210777.

 

Lee JY, Hall JA, Pokrovskii M, Kroehling L, Wu L, Littman DR. RORα enforces stability of the T-helper-17 cell effector program. BioRxiv. Doi: https://doi.org/10.1101/2020.12.15.422921.

 

Wu L#, Hollinshead KER, Hao Y, Au C, Kroehling L, Ng C, Lin WY, Li D, Silva HM, Shin J, Lafaille JJ, Possemato R, Pacold ME, Papagiannakopoulos TY, Kimmelman AC, Satija R, Littman DR#. Niche-selective inhibition of pathogenic Th17 cells by targeting metabolic redundancy. Cell. 2020. 182: 641-654. (# Corresponding author).

 

Lee JY, Hall JA, Kroehling L, Wu L, Najar T, Nguyen HH, Lin WY, Yeung ST, Silver HM, Li D, Hine A, Loke P, Hudesman D, Martin JC, Kenigsberg E, Merad M, Khanna KM, Littman DR. Serum amyloid A proteins induce pathogenic Th17 cells and promote inflammatory disease. Cell, 2020. 180: 79-91.

 

Hang S, Paik D, Devlin AS, Jamma T, Lu J, Ha S, Nelson BN, Kelly SP, Wu L, Zheng Y, Rastinejad F, Krout MR, Fischbach MA, Littman DR, Huh JR. Bile acid metabolites control Th17 and Treg cell differentiation. Nature, 2019. 576, 143–148.

 

Ng C, Aichinger M, Nguyen T, Au C, Najar T, Wu L, Mesa KR, Liao W, Quivy JP, Hubert B, Almouzni G, Zuber J, Littman DR. The histone chaperone CAF-1 cooperates with the DNA methyltransferases to maintain Cd4 silencing in cytotoxic T cells. Genes Dev. 2019. 33: 669-683.

 

Wu L*, Pan L*, Zhang C, Zhang M. Large protein assemblies formed by multivalent interactions between cadherin23 and harmonin suggest a stable anchorage structure at the tip link of stereocilia. JBC. 2012. 287: 33460-33471 (* equal contribution)

 

Wu L*, Pan L*, Wei Z, Zhang M. Structure of MyTH4-FERM domains in myosin VIIa tail bound to cargo. Science. 2011. 331:757-760 (* equal contribution)

 

Yan J, Pan L, Chen X, Wu L, Zhang M. The structure of the harmonin/sans complex reveals an unexpected interaction mode of the two Usher syndrome proteins. PNAS. 2010. 107: 4040-4045.

 

Pan L, Yan J, Wu L, Zhang M. Assembling stable hair cell tip link complex via multidentate interactions between harmonin and cadherin23. PNAS. 2009. 106: 5575-5580.