CNS regulation by the peripheral immune reaction
Peripheral immune system is constantly communicating with the Central Nervous System (CNS). We are particularly interested in understanding the mechanisms underlying the sensing by the CNS of the peripheral immune signals, in the form of either secreted proteins like cytokines, or immune cells that enter the CNS region as a result of peripheral inflammation, and such signal caused alterations in CNS development, function, and diseases. To this end, we have been developing novel genetic tools to visualize CNS cells that can received cytokines released from peripheral infection, building research platforms to study the role of T cells in the CNS (healthy and AD brain). We hope these studies could uncover novel mechanism governing brain function, and lead to new therapeutics for neurodegenerative diseases by targeting peripheral immune system.